Interplay between the immune system and adipose tissue in obesity. Exley MA, Hand L, O’Shea D, Lynch L. November 2014 Abstract Obesity is a major risk factor for metabolic disease, with white adipose tissue (WAT) inflammation emerging as a key underlying pathology. Alongside its major role in energy storage, WAT is an important endocrine organ, producing many bioactive molecules, termed adipokines,

Adipose invariant natural killer T cells. Lynch L. July 2014 Abstract Adipose tissue is a dynamic organ that makes up a substantial proportion of the body; in severe obesity it can account for 50% of body mass. Details of the unique immune system resident in human and murine adipose tissue are only recently emerging, and so it has remained a

Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1α-dependent inflammation. Tynan GA, Hearnden CH, Oleszycka E, Lyons CL, Coutts G, O’Connell J, Corrigan MA, Lynch L, Campbell M, Callanan JJ, Mok KH, Geoghegan J, O’Farrelly C, Allan SM, Roche HM, O’Shea DB, Lavelle EC. June 2014 Abstract Obesity is characterized by chronic inflammation associated with neutrophil and M1

Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus. Hogan AE, Gaoatswe G, Lynch L, Corrigan MA, Woods C, O’Connell J, O’Shea D. April 2014 Abstract Aims/hypothesis: Glucagon-like peptide 1 (GLP-1) is a gut hormone used in the treatment of type 2 diabetes mellitus. There is emerging evidence that GLP-1 has anti-inflammatory activity in

Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O’Shea D, O’Farrelly C, Exley MA. September 2021 Abstract Invariant natural killer T (iNKT) cells are evolutionarily conserved innate T cells that influence inflammatory responses. We have shown that iNKT

Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses. Hogan AE, Corrigan MA, O’Reilly V, Gaoatswe G, O’Connell J, Doherty DG, Lynch L, O’Shea D. September 2011 Abstract Invariant natural killer T (iNKT) cells are a minor subset of human T cells which express the invariant T cell receptor Vα24 Jα18 and recognize glycolipids presented

Commitment of decidual haematopoietic progenitor cells in first trimester pregnancy. Szereday L, Miko E, Meggyes M, Barakonyi A, Farkas B, Varnagy A, Bodis J, Lynch L, O’Farrelly C, Szekeres-Bartho J. January 2012 Abstract PROBLEM The aim of this study was to investigate the phenotype and commitment of decidual haematopoietic progenitor cells (HPCs) in healthy pregnant women and in women with early

Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects. Exley MA, Lynch L, Varghese B, Nowak M, Alatrakchi N, Balk SP. August 2011 Abstract Invariant natural killer T-cells (‘iNKT’) are the best-known CD1d-restricted T-cells, with recently-defined roles in controlling adaptive immunity. CD1d-restricted T-cells can rapidly produce large amounts of Th1 and/or Th2//Treg/Th17-type cytokines, thereby regulating

The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity. O’Connell J, Lynch L, Cawood TJ, Kwasnik A, Nolan N, Geoghegan J, McCormick A, O’Farrelly C, O’Shea D. April 2010 Abstract Objective: Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible for this phenomenon.