Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB. September 2017 Abstract M2 macrophages, innate lymphoid type 2 cells (ILC2s), eosinophils, Tregs, and invariant NK T cells (iNKT cells) all help to control adipose tissue inflammation, while

Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O’Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O’Shea D, Brenner MB, von Andrian U, Lynch L. February 2017 Abstract Adipose tissue has a dynamic immune system that adapts to changes in diet and maintains

Adipose tissue at the nexus of systemic and cellular immunometabolism. Kohlgruber AC, LaMarche NM, Lynch L. October 2016 Abstract At the simplest interpretation of the word, Immunometabolism describes the intersection of the fields of immunology and metabolism. With rapidly growing interest in this field, the term has expanded, and now encompasses a variety of concepts and definitions shaped by an individual’s

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy. Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O’Shea D, Brenner M. September 2016 Abstract Adipose-resident invariant natural killer T (iNKT) cells are key players in

Surgical injury induces local and distant adipose tissue browning. Longchamp A, Tao M, Bartelt A, Ding K, Lynch L, Hine C, Corpataux JM, Kristal BS, Mitchell JR, Ozaki CK. November 2015 Abstract The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue

Altered distribution and increased IL-17 production by mucosal-associated invariant T cells in adult and childhood obesity Carolan E, Tobin LM, Mangan BA, Corrigan M, Gaoatswe G, Byrne G, Geoghegan J, Cody D, O’Connell J, Winter DC, Doherty DG, Lynch L, O’Shea D, Hogan AE. June 2015 Abstract Mucosal-associated invariant T (MAIT) cells are innate MHC-unrestricted cells that regulate inflammatory responses through

Adipose tissue inflammation in the pathogenesis of type 2 diabetes. Kohlgruber A, Lynch L. November 2015 Abstract At least 2.8 million people die each year as a result of being overweight or obese, and the biggest burden being obesity-related diseases. Overweight and obesity account for a major proportion of type 2 diabetes (T2D) cases. Obesity is associated with inflammation in adipose

The transcriptional programs of iNKT cells. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. February 2015 Abstract Invariant natural killer T (iNKT) cells are innate T cells that express a semi-invariant T cell receptor (TCR) and recognize lipid antigens presented by CD1d molecules. As part of innate immunity, iNKT cells rapidly produce large amounts of cytokines after activation and

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant’Angelo DB, von Andrian U, Brenner MB. January 2015 Abstract Invariant natural killer T