Publications
Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model.
Invariant NKT cell-augmented GM-CSF-secreting tumor vaccine is effective in advanced prostate cancer model. Varghese B, Lynch L, Vriend LE, Draganov D, Clark JM, Kissick HT, Varghese S, Sanda MG, Dranoff G, Arredouani MS, Balk SP, Exley MA. December 2022 Abstract Invariant natural killer T cells (iNKT cells) express a semi-invariant T cell receptor that recognizes certain glycolipids (including α-galactosylceramide, αGC) bound
Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O’Shea D, Brennan D, Lynch L. March 2022 Read More Here
High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue.
High-Fat Diet Rapidly Modifies Trafficking, Phenotype, and Function of Plasmacytoid Dendritic Cells in Adipose Tissue. Stutte S, Ishikawa-Ankerhold H, Lynch L, Eickhoff S, Nasiscionyte S, Guo C, van den Heuvel D, Setzensack D, Colonna M, Maier-Begandt D, Weckbach L, Brocker T, Schulz C, Walzog B, von Andrian U. March 2022 Abstract Plasmacytoid dendritic cells (pDCs) display an increased abundance in visceral
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function.
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function. Dyck L, Prendeville H, Raverdeau M, Wilk MM, Loftus RM, Douglas A, McCormack J, Moran B, Wilkinson M, Mills EL, Doughty M, Fabre A, Heneghan H, LeRoux C, Hogan A, Chouchani ET, O’Shea D, Brennan D, Lynch L. March 2022 Abstract Obesity is one of the
Diet, Lipids, and Antitumor Immunity.
Diet, Lipids, and Antitumor Immunity. Prendeville H, Lynch L. March 2022 Abstract Tumour growth and dissemination is largely dependent on nutrient availability. It has recently emerged that the tumour microenvironment is rich in a diverse array of lipids that increase in abundance with tumour progression and play a role in promoting tumour growth and metastasis. Here, we describe the pro-tumorigenic roles
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation.
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation. Mills EL, Harmon C, Jedrychowski MP, Xiao H, Gruszczyk AV, Bradshaw GA, Tran N, Garrity R, Laznik-Bogoslavski D, Szpyt J, Prendeville H, Lynch L, Murphy MP, Gygi SP, Spiegelman BM, Chouchani ET. January 2022 Abstract Uncoupling protein 1 (UCP1) is a major regulator of brown and beige adipocyte energy
The therapeutic and prognostic implications of immunobiology in colorectal cancer: A Review.
The therapeutic and prognostic implications of immunobiology in colorectal cancer: A Review. Zaborowski AM, Winter DC, Lynch L. November 2021 Abstract Colorectal cancer represents the second leading cause of cancer-related death worldwide. The therapeutic field of immuno-oncology has rapidly gained momentum, with strikingly promising results observed in clinical practice. Increasing emphasis has been placed on the role of the immune response
Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines.
Type II NKT Cell Agonist, Sulfatide, Is an Effective Adjuvant for Oral Heat-Killed Cholera Vaccines. Albutti A, Longet S, McEntee CP, Quinn S, Liddicoat A, Rîmniceanu C, Lycke N, Lynch L, Cardell S, Lavelle EC. June 2021 Abstract Oral vaccination has the potential to offer a safer and more efficacious approach for protection against enteric pathogens than injection-based approaches, especially in
UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
UCP1 governs liver extracellular succinate and inflammatory pathogenesis. Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. May 2021 Abstract Non-alcoholic fatty liver disease (NAFLD), the most prevalent liver pathology worldwide, is intimately linked with obesity and type 2 diabetes.