Publications
Science Immunology: Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer
Science Immunology: Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer By Karen Slattery & Team Abstract High-grade serous ovarian cancer (HGSOC) remains an urgent unmet clinical need, with more than 70% of patients presenting with metastatic disease. Many patients develop large volumes of ascites, which promotes metastasis and is associated with poor therapeutic response and
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis.
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis. Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim WV, Kongthong S, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S; Accelerating Medicines Partnership: RA/SLE Network; Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB. November 2024 Abstract Fibroblasts play critical roles in
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis.
Rhythmic IL-17 production by γδ T cells maintains adipose de novo lipogenesis. Douglas A, Stevens B, Rendas M, Kane H, Lynch E, Kunkemoeller B, Wessendorf-Rodriguez K, Day EA, Sutton C, Brennan M, O’Brien K, Kohlgruber AC, Prendeville H, Garza AE, O’Neill LAJ, Mills KHG, Metallo CM, Veiga-Fernandes H, Lynch L. October 2024 Abstract The circadian rhythm of the immune system helps
Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023.
Adiposity, immunity, and inflammation: interrelationships in health and disease: a report from 24th Annual Harvard Nutrition Obesity Symposium, June 2023. Burak MF, Stanley TL, Lawson EA, Campbell SL, Lynch L, Hasty AH, Domingos AI, Dixit VD, Hotamışlıgil GS, Sheedy FJ, Dixon AE, Brinkley TE, Hill JA, Donath MY, Grinspoon SK. July 2024 Abstract The rapidly evolving field of immunometabolism explores how
γδ T cells as unconventional targets of checkpoint blockade.
γδ T cells as unconventional targets of checkpoint blockade. Widlund HR, Lynch L. April 2024 Read More Here
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans.
Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans. Scott B, Day EA, O’Brien KL, Scanlan J, Cromwell G, Scannail AN, McDonnell ME, Finlay DK, Lynch L. April 2024 Abstract Metformin, a widely used first-line treatment for type 2 diabetes (T2D), is known to reduce blood glucose levels and suppress appetite. Here we report a significant elevation of
Immune activation state modulates infant engram expression across development.
Immune activation state modulates infant engram expression across development. Power SD, Stewart E, Zielke LG, Byrne EP, Douglas A, Ortega-de San Luis C, Lynch L, Ryan TJ. August 2023 Abstract Infantile amnesia is possibly the most ubiquitous form of memory loss in mammals. We investigated how memories are stored in the brain throughout development by integrating engram labeling technology with mouse
Interleukin-17 as a key player in neuroimmunometabolism.
Interleukin-17 as a key player in neuroimmunometabolism. Douglas A, Stevens B, Lynch L. August 2023 Abstract In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression throughout evolution, dating as far back as cnidaria, molluscs and worms, which predate lymphocytes. The evolutionary conservation of IL-17 suggests that it is involved in innate
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors.
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors. Harmon C, Zaborowski A, Moore H, St Louis P, Slattery K, Duquette D, Scanlan J, Kane H, Kunkemoeller B, McIntyre CL, Scannail AN, Moran B, Anderson AC, Winter D, Brennan D, Brehm MA, Lynch L. August 2023 Abstract γδ T cells are important tissue-resident, innate T